Sheldon talking about his Mother’s sex life is comedy gold.

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Sheldon: “Can you recommend a surface you haven’t had coitus on?”

Sheldon: “How long have you been seeing him?”
Mrs. Cooper: “A few months”
Sheldon: “and how many of those months were you a demented sex pervert?”

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Bernadette: “Speak for yourself, last month my company invented and cured restless eye syndrome.”

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Sheldon: “I beg to differ. I used to live in those genitals. If someone wants to move into my old room, I should at least get a vote.”

Sheldon: “I love my Mother… even if she fornicates like a demonic weasel.”

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Sheldon: “You used to be protected by your Pre-Enlightenment mythology. Now you’re going to need a stronger friend, named Latex.”

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Mrs. Cooper: “Are you having the sex talk with me?”
Sheldon: “Well someone has to.”
Mrs. Cooper: “Oh, dear Lord”
Sheldon: “Don’t look at him. He’s mad at you.”